Document Detail


Cytoplasmic-to-nuclear volume ratio affects AP-1 complex formation as an indicator of cell cycle responsiveness.
MedLine Citation:
PMID:  15642355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytoplasmic volume undergoes a series of changes during mitosis in eukaryotes; in turn, signaling events such as osmotic stress can regulate the cytoplasmic volume in cells. In some organisms, increase in cytoplasmic-to-nuclear volume ratio was seen to affect the growth potential in cells, however, the mechanistics of such a regulation, if at all present, was unclear. In a computational model, we have constructed a growth factor-induced signaling pathway leading to AP-1 heterodimer formation through transcriptional regulation, and analyzed the effects of increasing the cytoplasmic-to-nuclear ratio on c-jun transcription and AP-1 complex. We have observed that larger cytoplasmic volumes caused both an increase in the final AP-1 product and a delay in the time of AP-1 accumulation.
Authors:
Izzet Oney; Isil Aksan Kurnaz; M Levent Kurnaz
Related Documents :
12929935 - Decreased ap-1 activity and interleukin-11 expression by bone marrow stromal cells may ...
25310895 - Microrna-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung aden...
12138125 - Regulation of gli1 transcriptional activity in the nucleus by dyrk1.
12093805 - Role of ap-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathio...
9298935 - Quantitative analysis of cytokine mrna expression in peripheral blood mononuclear cells...
14516665 - Cloning and expression of a novel armadillo motif containing gene in xenopus.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  579     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-03-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
Affiliation:
Institute of Biomedical Engineering, Boğaziçi University, Bebek, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
Cell Nucleus / physiology*
Cell Size
Computational Biology
Computer Simulation
Cytoplasm / physiology*
Epidermal Growth Factor / pharmacology,  physiology
Mitogen-Activated Protein Kinase Kinases / physiology
Models, Biological
Proto-Oncogene Proteins c-fos / genetics,  physiology
Proto-Oncogene Proteins c-jun / genetics,  physiology
Signal Transduction*
Transcription Factor AP-1 / metabolism*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; 62229-50-9/Epidermal Growth Factor; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.
Next Document:  Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its...