| Cytoplasmic phase separation in formation of galactosemic cataract in lenses of young rats. | |
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MedLine Citation:
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PMID: 16592709 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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We have determined the age dependence of the characteristics of the cytoplasmic phase separation of lenses from normal and galactosemic young rats. In the normal lens, the temperature at which the phase separation occurs decreases monotonically with age. In the lenses of rats fed with a high galactose diet, the phase separation temperature becomes increasingly higher with the development of galactosemia. When the phase separation temperature becomes higher than the ocular temperature, the nuclear opacity appears in vivo. The opacity is the result of light scattering by spatial fluctuations of the refractive index formed by interspersed regions of two separated phases in the fiber cell cytoplasm. This shows that the nuclear opacity that develops in the lens of galactosemic rats is the manifestation of phase separation of the lens fiber cytoplasm. |
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Authors:
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C Ishimoto; P W Goalwin; S T Sun; I Nishio; T Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 76 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-06-29 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 4414-6 Citation Subset: - |
Affiliation:
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Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. |
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