Document Detail

Cytoplasmic leucine naphthylamidase activity expressed in signet-ring cell carcinoma of the stomach.
MedLine Citation:
PMID:  200755     Owner:  NLM     Status:  MEDLINE    
Histochemical studies were performed on signet-ring cells in surgically resected gastric carcinomas from 64 patients. On the basis of periodic acid-Schiff reactivity of the intracellular mucin, the signet-ring cells were classified as type A (immature), type B (intermediate), or type C (mature). Different staining reactions to Alcian blue at pH 2.5 enabled type C cells to be subclassified as C-1 or C-2. In 63 cases (98.4%), intense leucine naphthylamidase (LNAase) activity was found histochemically in the cytoplasm of nearly all cancer cells except type C-2. Localization of LNAase activity in the cytoplasm was confirmed by conventional biochemical assay. From the present results, histochemical characteristics of signet-ring cell carcinoma are discussed.
K Kubota; S Yamada; M Ito; W Nakamura; T Nagayo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  59     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1599-604     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma, Mucinous / enzymology*,  pathology
Cytoplasm / enzymology
Epithelium / enzymology
Leucyl Aminopeptidase / metabolism*
Stomach Neoplasms / enzymology*,  pathology
Reg. No./Substance:
EC Aminopeptidase

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