Document Detail


Cytoplasmic leucine naphthylamidase activity expressed in signet-ring cell carcinoma of the stomach.
MedLine Citation:
PMID:  200755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Histochemical studies were performed on signet-ring cells in surgically resected gastric carcinomas from 64 patients. On the basis of periodic acid-Schiff reactivity of the intracellular mucin, the signet-ring cells were classified as type A (immature), type B (intermediate), or type C (mature). Different staining reactions to Alcian blue at pH 2.5 enabled type C cells to be subclassified as C-1 or C-2. In 63 cases (98.4%), intense leucine naphthylamidase (LNAase) activity was found histochemically in the cytoplasm of nearly all cancer cells except type C-2. Localization of LNAase activity in the cytoplasm was confirmed by conventional biochemical assay. From the present results, histochemical characteristics of signet-ring cell carcinoma are discussed.
Authors:
K Kubota; S Yamada; M Ito; W Nakamura; T Nagayo
Related Documents :
3354075 - Ultrastructure of renal adenoma.
6328815 - Neuroendocrine (merkel-cell) carcinoma of the skin. fine needle aspiration cytology and...
16035505 - Establishment and characterization of a human ovarian small cell carcinoma, hypercalcem...
8773185 - In vitro effect of ciprofloxacin on ht-29 human colon carcinoma cell line: assessment o...
8621775 - Nitric oxide synthase (nos3) and contractile responsiveness to adrenergic and cholinerg...
2316665 - Whole-cell currents in rat cortical collecting tubule: low-na diet increases amiloride-...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  59     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1599-604     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Mucinous / enzymology*,  pathology
Cytoplasm / enzymology
Epithelium / enzymology
Female
Humans
Leucyl Aminopeptidase / metabolism*
Male
Stomach Neoplasms / enzymology*,  pathology
Chemical
Reg. No./Substance:
EC 3.4.11.1/Leucyl Aminopeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Leukocyte migration in ovarian carcinoma: comparison of inhibitory activity of tumor extracts.
Next Document:  Cyclic nucleotide phosphodiesterase and protein activator in human cancer cell lines and Brown-Pearc...