Document Detail

Cytoplasmic immunoglobulins in chronic lymphocytic leukemia B cells.
MedLine Citation:
PMID:  3103709     Owner:  NLM     Status:  MEDLINE    
It is generally assumed that chronic lymphocytic leukemia of B cell origin (B-CLL) is characterized by the presence of surface membrane immunoglobulins (SmIg) and by the absence of cytoplasmic immunoglobulins (CyIg). In a variable number of cases SmIg are not detectable because of their low density on the cellular surface. Because a constant presence of CyIg in 20 subjects suffering from B-CLL has been reported recently, we reexamined 15 SmIg-negative and 10 SmIg-positive B-CLL patients by SmIg and CyIg determinations. We used a direct immunofluorescence method on peripheral blood mononuclear cells for the detection of SmIg and, after fixation, for CyIg. CyIg were detectable in 24 out of 25 cases, with a fluorescence intensity ranging from weak to moderate. The existence of frequent negative results for CyIg determination in B-CLL reported in the literature probably depends on the low sensitivity of the method used. We conclude that CyIg determination is useful in phenotyping every B-CLL patient, especially SmIg-negative ones.
G Pianezze; I Gentilini; M Casini; P Fabris; P Coser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood     Volume:  69     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-05-07     Completed Date:  1987-05-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1011-4     Citation Subset:  AIM; IM    
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MeSH Terms
Antigens, Neoplasm / analysis
Antigens, Surface / analysis
B-Lymphocytes / immunology*
Clone Cells
Cytoplasm / immunology
Fluorescent Antibody Technique
Immunoglobulin Heavy Chains / analysis
Immunoglobulin Light Chains / analysis
Immunoglobulins / analysis*
Leukemia, Lymphoid / immunology*
Receptors, Antigen, B-Cell / analysis
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Light Chains; 0/Immunoglobulins; 0/Receptors, Antigen, B-Cell

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