| Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains. | |
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MedLine Citation:
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PMID: 22157083 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cytoplasmic dynein is a homodimeric AAA+ motor that transports a multitude of cargos toward the microtubule minus end. How the two catalytic head domains interact and move relative to each other during processive movement is unclear. Here, we tracked the relative positions of both heads with nanometer precision and directly observed the heads moving independently along the microtubule. The heads remained widely separated, and their stepping behavior varied as a function of interhead separation. One active head was sufficient for processive movement, and an active head could drag an inactive partner head forward. Thus, dynein moves processively without interhead coordination, a mechanism fundamentally distinct from the hand-over-hand stepping of kinesin and myosin. |
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Authors:
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Mark A Dewitt; Amy Y Chang; Peter A Combs; Ahmet Yildiz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-8 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: - ISSN: 1095-9203 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physics, and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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