Document Detail


Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission.
MedLine Citation:
PMID:  16194274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Several studies conducted in areas of medium or low malaria transmission intensity have found associations between malaria immunity and plasma antibody levels to glutamate rich protein (GLURP). This study was conducted to analyse if a similar relationship could be documented in an area of intense malaria transmission. METHODS: A six month longitudinal study was conducted in an area of holoendemic malaria transmission in north-eastern Tanzania, where the incidence of febrile malaria decreased sharply by the age of three years, and anaemia constituted a significant part of the malaria disease burden. Plasma antibodies to glutamate rich protein (GLURP) were analysed and related with protection against malaria morbidity in models correcting for the effect of age. RESULTS: The risk of febrile malaria episodes was reduced significantly in children with measurable anti-GLURP IgG1 antibodies at enrollment [adjusted odds ratio: 0.39 (95% CI: 0.15, 0.99); P = 0.047]. Interestingly, there was an inverse relationship between the plasma anti-GLURP IgG1 and IgG3 levels and the levels of parasitaemia at enrollment. However, anti-GLURP IgG2 and IgG4 levels were not associated with reduction in parasite density. Similarly, antibody levels were not associated with haemoglobin levels or anaemia risk. CONCLUSION: Cytophilic IgG1 and IgG3 antibodies against R0-GLURP may contribute to the control of parasite multiplication and reduction in febrile malaria incidence in children living in an area of intense malaria transmission.
Authors:
John P A Lusingu; Lasse S Vestergaard; Michael Alifrangis; Bruno P Mmbando; Michael Theisen; Andrew Y Kitua; Martha M Lemnge; Thor G Theander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-29
Journal Detail:
Title:  Malaria journal     Volume:  4     ISSN:  1475-2875     ISO Abbreviation:  Malar. J.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-24     Completed Date:  2006-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101139802     Medline TA:  Malar J     Country:  England    
Other Details:
Languages:  eng     Pagination:  48     Citation Subset:  IM    
Affiliation:
National Institute for Medical Research, Amani Medical Research Centre, Tanga & Headquarters, Dar es Salaam, Tanzania. jpalusingu@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / etiology
Animals
Antibodies, Protozoan / blood
Child
Child, Preschool
Humans
Immunoglobulin G / blood
Infant
Infant, Newborn
Logistic Models
Malaria, Falciparum / complications,  immunology*,  transmission
Plasmodium falciparum / metabolism*
Protozoan Proteins / immunology*,  metabolism
Risk Factors
Tanzania / epidemiology
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Immunoglobulin G; 0/Protozoan Proteins; 145112-81-8/glutamate-rich protein, Plasmodium
Comments/Corrections

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