Document Detail

Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis.
MedLine Citation:
PMID:  18703335     Owner:  NLM     Status:  MEDLINE    
Cells use a variety of intercellular structures, including gap junctions and synapses, for cell-cell communication. Here, we present recent advances in the understanding of thin membrane bridges that function in cell-cell signaling and intercellular transport. Cytonemes or filopodial bridges connect neighboring cells via mechanisms of adhesion, which enable ligand-receptor-mediated transfer of surface-associated cargoes from cell to cell. By contrast, tunneling nanotubes establish tubular conduits between cells that provide for the exchange of both cell-surface molecules and cytoplasmic content. We propose models for the biogenesis of both types of membrane bridges and describe how viruses use these structures for the purpose of cell-to-cell spread.
Nathan M Sherer; Walther Mothes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-14
Journal Detail:
Title:  Trends in cell biology     Volume:  18     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-29     Completed Date:  2008-11-28     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
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MeSH Terms
Cell Adhesion / physiology*
Cell Communication / physiology*
Cell Surface Extensions / physiology*,  ultrastructure
Gap Junctions / physiology*,  ultrastructure
Intercellular Junctions / physiology*,  ultrastructure
Pseudopodia / physiology,  ultrastructure
Synapses / physiology
Viruses / metabolism
Grant Support
CA098727/CA/NCI NIH HHS; R01 CA098727/CA/NCI NIH HHS; R01 CA098727-06/CA/NCI NIH HHS

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