Document Detail


Cytomorphology of ALK+ anaplastic large cell lymphoma displaying spindle cells mimicking a sarcomatous tumor: Report of a case.
MedLine Citation:
PMID:  20890996     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Anaplastic large cell lymphoma (ALCL) is a lymphoma of T-cell or null-cell lineage characterized by molecular abnormalities involving anaplastic lymphoma kinase (ALK) gene and expression of ALK protein and CD30. Cytologic diagnosis of this entity is often a challenge and diagnostic difficulties are encountered when cytomorphology deviates from the usual descriptions. The reports of FNAC diagnosis of ALCL are rather limited. Histology and immunohistochemistry are usually required to confirm the diagnosis. We discuss a case of ALCL suspected on cytology in which a differential diagnosis of soft tissue sarcoma was also considered because of the presence of spindle-shaped and strap cells. Histology and immunohistochemistry confirmed the diagnosis of ALK+ ALCL with tumor cells displaying strong immunoreactivity for leucocyte common antigen, CD3, ALK-1 and CD30. We emphasize that the cytological features which may help in distinguishing sarcomatoid ALCL from soft tissue sarcoma are the presence of "hallmark cells," lymphoglandular bodies and admixed mature small lymphocytes. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc.
Authors:
Mukul Vij; Bonnie Dhir; Ritu Verma; Vinita Agrawal; Vikas Agarwal; Sushila Jaiswal; Rakesh Pandey
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Publication Detail:
Type:  Journal Article     Date:  2010-10-01
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  39     ISSN:  1097-0339     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  775-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Affiliation:
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, UP, INDIA-226014.
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