Document Detail


Cytomegalovirus transmission to preterm infants during lactation.
MedLine Citation:
PMID:  18243784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Breastfeeding has a major impact on HCMV epidemiology. The incidence of postnatal HCMV reactivation during lactation equals the maternal seroprevalence. Infectious virus, viral DNA and RNA can be isolated easily from cell and fat-free milk whey. Early onset of viral DNAlactia and virolactia as well as high viral load in milk whey are maternal risk factors for virus transmission. The dynamics of HCMV reactivation can be described by unimodal kinetics with interindividual variation. Virus reactivation during lactation is a self-limiting local process in the absence of systemic HCMV infection. Preterm infants below 1000g birthweight and a gestational age below 30 weeks may be at high risk of acquiring a symptomatic HCMV infection. Several recent studies described low transmission rates and mostly asymptomatically infected neonates using frozen milk. Despite different freeze-storing procedures, HCMV transmissions occurred, and severe HCMV infections were observed. Few data exist on the long-term outcome of postnatally acquired HCMV infection via breast milk. To substantiate the international debate on the use of native or inactivated milk for feeding of preterm infants, additional data are necessary for better identification of mother-infant-pairs at risk for viral transmission and symptomatic infection early after birth.
Authors:
Klaus Hamprecht; Jens Maschmann; Gerhard Jahn; Christian F Poets; Rangmar Goelz
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  41     ISSN:  1386-6532     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  198-205     Citation Subset:  IM    
Affiliation:
Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tübingen, Elfriede-Aulhorn-Str 6, 72076 Tübingen, Germany. klaus.hamprecht@med.uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding*
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / transmission*,  virology
Female
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / virology*
Infant, Very Low Birth Weight
Infectious Disease Transmission, Vertical*
Lactation
Milk, Human / virology
Virus Activation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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