Document Detail

Cytomegalovirus retinitis in Wegener's granulomatosis: case report and review of the literature.
MedLine Citation:
PMID:  15799746     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To present the first case of cytomegalovirus (CMV) retinitis in a Wegener's granulomatosis patient on systemic cyclosporine A (CsA) therapy. METHODS: A 41-year-old patient was treated with systemic CsA for c-ANCA positive Wegener's granulomatosis. Four weeks later he presented with blurred vision and a retinitis was diagnosed in the right eye. After detection of CMV DNA by polymerase chain reaction (PCR), the patient was treated with intravenous gancyclovir. Due to bone marrow toxicity, systemic antiviral therapy was discontinued and an intravitreal gancyclovir pellet was implanted. RESULTS: The retinitis lesions were scarified under this therapy and the patient's visual function was restored completely. CONCLUSIONS: Cytomegalovirus retinitis can occur under systemic monotherapy with CsA in patients with systemic vasculitis. Intraocular virus DNA detection by PCR is recommended to rule out retinal involvement of the underlying vasculitis in atypical cases and to preserve the patient's visual acuity.
Eckart Bertelmann; Anja Liekfeld; Uwe Pleyer; Christian Hartmann
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  83     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-31     Completed Date:  2005-05-26     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  258-61     Citation Subset:  IM    
Clinic of Ophthalmology, Charité- University School of Medicine Berlin, Berlin, Germany.
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MeSH Terms
Antiviral Agents / therapeutic use
Cyclosporine / therapeutic use
Cytomegalovirus Retinitis / diagnosis,  drug therapy,  etiology*
DNA, Viral / analysis
Ganciclovir / therapeutic use
Immunosuppressive Agents / therapeutic use
Polymerase Chain Reaction
Wegener Granulomatosis / complications*,  diagnosis,  drug therapy
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; 82410-32-0/Ganciclovir

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