| Cytomegalovirus pp65 antigenemia after autologous marrow and peripheral blood stem cell transplantation. | |
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MedLine Citation:
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PMID: 8896489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective study, the cytomegalovirus (CMV) pp65 antigenemia assay was compared with detection of CMV by blood culture in 67 consecutive CMV-seropositive patients undergoing autologous marrow or peripheral blood stem cell transplantation. Antigenemia occurred in 26 patients (38.8%) a median of 33 days (range, 12-74) after transplant. Viremia was detected in 5 patients (7.5%) a median of 30 days (range, 12-74) after transplant and was treated with ganciclovir in 3. Antigenemia occurred sporadically at low levels (< 5 positive cells/slide) in 19 patients (28.4%) and never resulted in CMV disease. Two of 7 patients who presented with or progressed to antigenemia of > 5 positive cells/slide developed fatal CMV pneumonia 8 days later. Neither patient had CMV viremia before onset of pneumonia. Thus, quantitative CMV pp65 antigenemia may be useful in guiding antiviral treatment in seropositive autograft recipients. |
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Authors:
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M Boeckh; T Stevens-Ayers; R A Bowden |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 174 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1996-11-27 Completed Date: 1996-11-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 907-12 Citation Subset: AIM; IM |
Affiliation:
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Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, Seattle, WA 98104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Marrow Transplantation / adverse effects* Cytomegalovirus Infections / epidemiology* Female Hematopoietic Stem Cell Transplantation / adverse effects* Humans Male Middle Aged Phosphoproteins / blood* Prospective Studies Transplantation, Autologous Viral Matrix Proteins / blood* Viremia / epidemiology* |
| Grant Support | |
ID/Acronym/Agency:
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CA-18029/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphoproteins; 0/Viral Matrix Proteins; 0/cytomegalovirus matrix protein 65kDa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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