| Cytomegalovirus mediated myelosuppression. | |
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MedLine Citation:
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PMID: 12361756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytomegalovirus (CMV) has long been associated with myelosuppression. Evidence for this association has been provided from in vitro studies, statistical analysis of clinical studies, informative case reports, and murine models. Reports differ as to how CMV mediates myelosuppression. Some data indicate direct infection of hematopoietic progenitors and their progeny, others indicate that the supportive microenvironment is infected and thereby its supportive function compromised. In this report we review data suggesting that the severity of myelosuppression in patients is associated with particular CMV genotypes identified by variations in the glycoprotein B gene. |
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Authors:
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Julie Randolph-Habecker; Mineo Iwata; Beverly Torok-Storb |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Volume: 25 Suppl 2 ISSN: 1386-6532 ISO Abbreviation: J. Clin. Virol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-10-03 Completed Date: 2002-12-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9815671 Medline TA: J Clin Virol Country: Netherlands |
Other Details:
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Languages: eng Pagination: S51-6 Citation Subset: IM |
Affiliation:
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Transplantation Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells / physiology, virology Cells, Cultured Cytomegalovirus / genetics, pathogenicity* Cytomegalovirus Infections / physiopathology*, virology Female Fibroblasts Genetic Variation Hematopoiesis Hematopoietic Stem Cells / physiology*, virology Humans Mice Stem Cell Transplantation / adverse effects* Viral Envelope Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Viral Envelope Proteins; 0/glycoprotein B, Simplexvirus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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