Document Detail


Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation.
MedLine Citation:
PMID:  17376923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 months. In contrast, primary infection was accompanied by up-regulation of markers of activation (CD45R0 and HLA-D) on both CMV-specific cells and the overall CD8 T-cell population and division (Ki-67) of specific cells, but neither pattern persisted. At 12 months of age, the CD8 T-cell population of CMV-infected infants was more differentiated than that of uninfected infants. Although the subpopulation of CMV-specific cells remained constant, the CMV peptide-specific gamma interferon response was lower in younger infants and increased with age. As the CD8 T-cell phenotype induced by CMV is indicative of immune dysfunction in the elderly, the existence of a similar phenotype in large numbers of Gambian infants raises the question of whether CMV induces a similarly deleterious effect.
Authors:
David J C Miles; Marianne van der Sande; David Jeffries; Steve Kaye; Jamila Ismaili; Olubukola Ojuola; Mariama Sanneh; Ebrima S Touray; Pauline Waight; Sarah Rowland-Jones; Hilton Whittle; Arnaud Marchant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-21
Journal Detail:
Title:  Journal of virology     Volume:  81     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5766-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
CD8-Positive T-Lymphocytes / immunology*,  metabolism,  pathology*
Cell Differentiation / immunology*
Cells, Cultured
Cross-Sectional Studies
Cytomegalovirus / immunology*
Cytomegalovirus Infections / epidemiology,  immunology*,  pathology*
Female
Gambia / epidemiology
Humans
Immunophenotyping
Infant
Infant, Newborn
Longitudinal Studies
Lymphocyte Activation / immunology
Lymphocyte Count
Male
Grant Support
ID/Acronym/Agency:
MC_U190081978//Medical Research Council; MC_U190085854//Medical Research Council
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