Document Detail


Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods.
MedLine Citation:
PMID:  17566679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunohistochemical and molecularpathologic techniques have improved the diagnosis of myocarditis as compared with conventional histologic staining methods done according to the Dallas criteria. Additionally, immunohistochemistry and in situ-hybridization are able to demonstrate viral infection, e.g. cytomegaloviruses in salivary glands and lungs, locations both known to be involved in cytomegalovirusinfection. However, in many cases of proved cytomegalovirusinfection the cause of death remains unclear. We report on three children younger than 1-year of age, who died suddenly without prodromal symptoms. Their deaths were attributed to SIDS (sudden infant death syndrome). In situ-hybridization, immunohistochemical (LCA, CD45R0, CD68, MHC-class-II-molecules, E-selectine) and molecularpathologic investigations (PCR), however, suggested that death was caused by a cytomegalovirus-induced pneumonia or myocarditis. In the future, these methods should be used for investigating cases with suspicion of SIDS.
Authors:
Reinhard Dettmeyer; Jan P Sperhake; Jutta Müller; Burkhard Madea
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-13
Journal Detail:
Title:  Forensic science international     Volume:  174     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Affiliation:
Department of Forensic Medicine, University of Bonn, Stiftsplatz 12, D-53111 Bonn, Germany. rdettmey@uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Cytomegalovirus / genetics,  isolation & purification
Cytomegalovirus Infections / diagnosis*
DNA, Viral / isolation & purification
Diagnosis, Differential
Forensic Pathology
Humans
Immunohistochemistry
In Situ Hybridization
Infant
Lung / pathology,  virology
Male
Myocarditis / virology*
Myocardium / pathology
Pneumonia, Viral / diagnosis*
Polymerase Chain Reaction
Salivary Glands / pathology,  virology
Sudden Infant Death / diagnosis
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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