Document Detail

Cytomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors.
MedLine Citation:
PMID:  17267891     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We describe a case where Mirror syndrome was characterized by altered levels of antiangiogenic proteins (soluble fms-like tyrosine kinase 1 [sFlt1] and soluble endoglin). CASE: We describe a pregnant patient with severe fetal and placental edema induced by congenital cytomegalovirus (CMV) infection that was associated with preeclampsia. Fetal CMV was confirmed histologically, whereas antiangiogenic factors were demonstrated to be elevated in maternal but not fetal blood. The levels of sFlt1 and soluble endoglin in our patient's serum before delivery were 116.5 ng/mL (normal pregnancy 19.3 ng/mL and preeclampsia 66.0 ng/mL, representing mean values before delivery) and 107.4 ng/mL (normal pregnancy 18.7 ng/mL and preeclampsia 52.6 ng/mL, representing mean values before delivery), respectively. In contrast, the values of sFlt1 and soluble endoglin in the cord blood were relatively low at 2.1 ng/mL and 8.2 ng/mL, respectively. CONCLUSION: If this observation is confirmed, CMV infection may be cited as a cause of Mirror syndrome and preeclampsia phenotypes associated with this disorder may be related to increased circulating antiangiogenic factors.
Sarosh Rana; Shivalingappa Venkatesha; Monique DePaepe; Edward K Chien; Michael Paglia; S Ananth Karumanchi
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  109     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-02-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  AIM; IM    
Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA.
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MeSH Terms
Angiogenic Proteins / blood*
Cesarean Section
Cytomegalovirus Infections / blood,  complications,  congenital,  diagnosis*
Diagnosis, Differential
Fetal Diseases / blood,  diagnosis*
Infant, Newborn
Pre-Eclampsia / blood,  diagnosis*,  etiology
Pregnancy Trimester, Third
Prenatal Diagnosis*
Reg. No./Substance:
0/Angiogenic Proteins
Comment In:
Obstet Gynecol. 2007 May;109(5):1205-6; author reply 1206   [PMID:  17470610 ]
Erratum In:
Obstet Gynecol. 2007 May;109(5):1207

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