| Cytomegalovirus-induced infectious mononucleosis-like syndrome in a rheumatoid arthritis patient treated with methotrexate and infliximab. | |
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MedLine Citation:
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PMID: 20467180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a patient with rheumatoid arthritis (RA) who developed cytomegalovirus (CMV)-induced infectious mononucleosis-like syndrome (IMLS) while being treated with methotrexate and infliximab. She suddenly developed intermittent high fever and general fatigue with liver dysfunction, remarkable lymphocytosis and laboratory data suggestive of CMV reactivation. Her clinical symptoms quickly improved after the cessation of methotrexate and infliximab without the use of anti-viral drugs such as ganciclovir. CMV-induced IMLS might be a cause of persistent fever in RA patients, particularly when biologics are used for treatment. |
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Authors:
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Yasuhiro Shimojima; Wataru Ishii; Masayuki Matsuda; Hideyuki Nakazawa; Shu-Ichi Ikeda |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-14 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 937-40 Citation Subset: IM |
Affiliation:
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Department of Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Monoclonal / adverse effects* Antirheumatic Agents / adverse effects* Arthritis, Rheumatoid / drug therapy* Cytomegalovirus / pathogenicity Cytomegalovirus Infections / diagnosis, etiology* Diagnosis, Differential Female Humans Immunosuppressive Agents / adverse effects Infectious Mononucleosis / diagnosis, etiology* Methotrexate / adverse effects* Tumor Necrosis Factor-alpha / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Immunosuppressive Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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