Document Detail

Cytomegalovirus glycoprotein B gene polymorphism and its association with clinical presentations in infants.
MedLine Citation:
PMID:  19842410     Owner:  NLM     Status:  MEDLINE    
The clinical manifestations in cytomegalovirus infected-infants vary from asymptomatic illness to highly fatal cytomegalic inclusion disease. The influence of human cytomegalovirus (HCMV) strains on the outcome of HCMV disease is poorly explored. The present study was undertaken to explore the role of gB genotypes with clinical features in infants with clinically suspected HCMV disease. Urine samples of 71 infants (age < 1 year) with clinically suspected HCMV disease were subjected to amplification of glycoprotein B (gB) gene by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism using RsaI and HinfI. HCMV DNA could be detected in 12 samples by gB gene PCR, 6 of which comprised of gB2, followed by gB1 in 5 samples and gB3 in 1 sample. Organomegaly was the most common finding (67%) followed by jaundice (50%), pneumonia (50%), seizures (42%), microcephaly (25%), low birth weight (25%) and rashes (17%). No particular genotype was significantly associated with specific clinical presentation or organ system involvement.
Abhishek Mewara; Baijayantimala Mishra; Radha Kanta Ratho; Praveen Kumar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  40     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  759-64     Citation Subset:  IM    
Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Cytomegalovirus / genetics*,  isolation & purification
Cytomegalovirus Infections / urine,  virology*
Infant, Newborn
Polymorphism, Single Nucleotide / genetics*
Viral Envelope Proteins / genetics*
Reg. No./Substance:
0/Viral Envelope Proteins; 0/glycoprotein B, Simplexvirus

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