Document Detail


Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients.
MedLine Citation:
PMID:  8985216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB 1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with <100/microL CD4 cells, gB1 was found significantly less often than in allograft recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gBl and increased incidence of gB2 compared with allograft recipients was also seen in urine of HIV-infected patients and reflected the distribution seen in leukocytes. gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/microL CD4 cells. gB1-4 genotypes were similar in patients with < 100/microL CD4 cells with or without retinitis.
Authors:
L Rasmussen; C Hong; D Zipeto; S Morris; D Sherman; S Chou; R Miner; W L Drew; R Wolitz; A Dowling; A Warford; T C Merigan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  175     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-27     Completed Date:  1997-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  AIM; IM; X    
Affiliation:
Center for AIDS Research, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, CA 94305, USA. lucy.rasmussen@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / virology*
Amino Acid Sequence
Base Sequence
Cytomegalovirus / classification,  genetics*,  isolation & purification
Cytomegalovirus Infections / virology*
Cytomegalovirus Retinitis / virology
Genotype
Humans
Immunocompromised Host*
Leukocytes / virology
Male
Molecular Sequence Data
Opportunistic Infections / virology*
Pharynx / virology
Semen / virology
Transplantation Immunology
Transplantation, Homologous*
Urine / virology
Grant Support
ID/Acronym/Agency:
AI-05629/AI/NIAID NIH HHS

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