Document Detail

Cytomegalovirus encephalopathy in an infant with congenital acquired immuno-deficiency syndrome.
MedLine Citation:
PMID:  2172857     Owner:  NLM     Status:  MEDLINE    
A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.
L Belec; J Tayot; P Tron; J Mikol; F Scaravilli; F Gray
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neuropediatrics     Volume:  21     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM; X    
Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
AIDS-Related Complex / pathology
Brain / pathology
Cytomegalovirus Infections / congenital*,  pathology
Encephalitis / congenital*,  pathology
HIV Seropositivity / congenital*
Inclusion Bodies, Viral / ultrastructure
Infant, Newborn
Infant, Premature, Diseases / pathology*
Microscopy, Electron
Opportunistic Infections / congenital*,  pathology

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