| Cytomegalovirus disease as a possible etiologic factor for early atherosclerosis. | |
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MedLine Citation:
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PMID: 10646245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A group of 284 patients who underwent orthotopic heart transplantation between April 1986 to June 1991 and who were followed up for at least five years was analyzed in this paper. Patients were divided into three groups according to the presence or absence of cytomegalovirus infection or disease: patients without infection, patients with serologycaly proven infection and patients with cytomegalovirus disease. The analysis of survival was performed with respect to all major factors that influence survival: age and sex of a donor and a recipient, number of rejection episodes, perioperative ischemic time and pulmonary vascular resistence. A recipient's age was shown to be a significant factor. Patients who experienced at least one episode of cytomegalovirus disease had significantly worse long-term survival compared to those with the infection only or without the infection. That difference was caused by the increased incidence of coronary atherosclerosis, which caused deaths in patients with a previous episode of cytomegalovirus disease. A possible mechanism responsible for this phenomenon is discussed. |
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Authors:
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B Biocina; I Husedzinović; Z Sutlić; V Presecki; J Wallwork |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Collegium antropologicum Volume: 23 ISSN: 0350-6134 ISO Abbreviation: Coll Antropol Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-23 Completed Date: 2000-02-23 Revised Date: 2009-02-04 |
Medline Journal Info:
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Nlm Unique ID: 8003354 Medline TA: Coll Antropol Country: CROATIA |
Other Details:
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Languages: eng Pagination: 673-81 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Clinic of Surgery, Clinical Hospital Dubrava, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Artery Disease
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epidemiology,
virology* Cytomegalovirus Infections / complications*, epidemiology Female Follow-Up Studies Heart Transplantation / mortality* Humans Immunosuppression Incidence Male Middle Aged Proportional Hazards Models Risk Factors Survival Rate Time Factors |
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