Document Detail


Cytomegalovirus disease as a possible etiologic factor for early atherosclerosis.
MedLine Citation:
PMID:  10646245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A group of 284 patients who underwent orthotopic heart transplantation between April 1986 to June 1991 and who were followed up for at least five years was analyzed in this paper. Patients were divided into three groups according to the presence or absence of cytomegalovirus infection or disease: patients without infection, patients with serologycaly proven infection and patients with cytomegalovirus disease. The analysis of survival was performed with respect to all major factors that influence survival: age and sex of a donor and a recipient, number of rejection episodes, perioperative ischemic time and pulmonary vascular resistence. A recipient's age was shown to be a significant factor. Patients who experienced at least one episode of cytomegalovirus disease had significantly worse long-term survival compared to those with the infection only or without the infection. That difference was caused by the increased incidence of coronary atherosclerosis, which caused deaths in patients with a previous episode of cytomegalovirus disease. A possible mechanism responsible for this phenomenon is discussed.
Authors:
B Biocina; I Husedzinović; Z Sutlić; V Presecki; J Wallwork
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Collegium antropologicum     Volume:  23     ISSN:  0350-6134     ISO Abbreviation:  Coll Antropol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-23     Completed Date:  2000-02-23     Revised Date:  2009-02-04    
Medline Journal Info:
Nlm Unique ID:  8003354     Medline TA:  Coll Antropol     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  673-81     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, Clinic of Surgery, Clinical Hospital Dubrava, Zagreb, Croatia.
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Disease / epidemiology,  virology*
Cytomegalovirus Infections / complications*,  epidemiology
Female
Follow-Up Studies
Heart Transplantation / mortality*
Humans
Immunosuppression
Incidence
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Survival Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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