Document Detail


Cytomegalovirus Retinitis Following Intravitreal Triamcinolone Acetonide in a Patient with Chronic Uveitis on Systemic Immunosuppression.
MedLine Citation:
PMID:  23282087     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Purpose: To report a case of cytomegalovirus (CMV) retinitis in an HIV-negative, iatrogenically immunosuppressed patient with chronic uveitis following intravitreal triamcinolone acetonide (IVTA). Design: Observational case report. Methods: A 56-year-old female with chronic idiopathic panuveitis on azathioprine received a single 4-mg IVTA injection for macular edema and presented after 6 months with severe retinitis. Results: CMV was confirmed by polymerase chain reaction of vitreous fluid. The retinitis responded well to intravitreal ganciclovir, but she developed a rhegmatogenous retinal detachment and underwent vitrectomy with silicone oil tamponade. Conclusions: Sight-threatening CMV retinitis may develop in HIV-negative, immunosuppressed individuals after IVTA. Regular fundoscopy for up to 9 months after IVTA is recommended.
Authors:
Anthony Grant Zaborowski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  -     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, Nelson R. Mandela School of Medicine , University of KwaZulu-Natal , Durban, South Africa.
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