| Cytolytic CD4(+) T cells in viral immunity. | |
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MedLine Citation:
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PMID: 21105780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is generally believed that the role of CD4(+) T cells is to coordinate the different arms of the adaptive immune system to shape an effective response against a pathogen and regulate nonessential or deleterious activities. However, a growing body of evidence suggests that effector CD4(+) T cells can directly display potent antiviral activity themselves. The presence of cytolytic CD4(+) T cells has been demonstrated in the immune response to numerous viral infections in both humans and in animal models and it is likely that they play a critical role in the control of viral replication in vivo. This article describes the current research on virus-specific cytolytic CD4(+) T cells, with a focus on HIV-1 infection and the implications that this immune response has for vaccine design. |
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Authors:
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Damien Z Soghoian; Hendrik Streeck |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert review of vaccines Volume: 9 ISSN: 1744-8395 ISO Abbreviation: Expert Rev Vaccines Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2011-03-02 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101155475 Medline TA: Expert Rev Vaccines Country: England |
Other Details:
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Languages: eng Pagination: 1453-63 Citation Subset: IM |
Affiliation:
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Ragon Institute of MGH, MIT and Harvard Massachusetts General Hospital, Harvard Medical School Building 149, 13th Street, 5th floor, #5217, Charlestown, Boston, MA 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD4-Positive T-Lymphocytes / immunology* HIV Infections / immunology Humans T-Lymphocyte Subsets / immunology* T-Lymphocytes, Cytotoxic / immunology* Virus Diseases / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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1R01AI091450-01/AI/NIAID NIH HHS; R01 AI091450-01/AI/NIAID NIH HHS; R01 AI091450-02/AI/NIAID NIH HHS |
| Comments/Corrections | |
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