Document Detail


Cytology and colchicine sensitivity of viable cells from lymph nodes with malignant lymphoma.
MedLine Citation:
PMID:  348297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Viable cell suspensions were prepared from 31 nodes diagnosed non-Hodgkin's malignant lymphoma, and from 30 non-malignant nodes. The cells were examined and counted by phase contrast microscopy. The suspensions were characterized by the percentage of large cells and by a colchicine-sensitivity index. The finding of more than 6% large cells or the finding of a sensitivity index of more than 30% was considered a positive test for a malignant lymphoma. According to these criteria there were 2 false positives in 30 reactive nodes and one false negative in 31 malignant nodes. Findings on 3 nodes diagnosed angioimmunoblastic lymphadenopathy suggested malignancy. The colchicinesensitivity index of blood lymphocytes seemed useful for monitoring lymphoma patients for leukemic involvement.
Authors:
R Schrek; Z Molnar; S S Stefani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  41     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1845-56     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Colchicine / pharmacology*
Drug Resistance
Humans
Lymph Nodes / pathology*
Lymphatic Diseases / pathology
Lymphocytes / drug effects*
Lymphoma / blood,  diagnosis,  pathology*
Lymphoma, Large B-Cell, Diffuse / pathology
Lymphoma, Non-Hodgkin / pathology
Neoplastic Cells, Circulating
Chemical
Reg. No./Substance:
64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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