Document Detail

Cytological and tissue eosinophilia correlations in nasal polyposis.
MedLine Citation:
PMID:  21144220     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Eosinophilic nasal mucosal infiltration is characteristic of nasal polyposis. The aim of this work was to study the possibility of correlations between cytological and tissue eosinophilia in patients with nasal polyposis and with the stage of the disease. If this correlation exists, nasal cytology will be very useful in diagnosis and management of patients with nasal polyposis.
METHODS: We studied 40 patients affected idiopathic nasal polyposis and 12 normal group controls. Qualitative measurements of eosinophils in nasal exudates and in tissue biopsy specimens were performed and the results were compared.
RESULTS: Nasal cytology and tissue biopsy showed a statistical correlation in the normal as well as in the pathological group. Clinical staging polyposis also correlated with cytological and tissue eosinophilia.
CONCLUSIONS: Nasal cytological eosinophilia is a simple, fast, nontraumatic, and inexpensive method in the evaluation of patients with nasal polyposis. Eosinophilic infiltration of the nasal mucosa is characteristic of nasal polyposis. It correlates with the stage of the disease and tends to be higher in patients with asthma, nasal polyposis, and nonsteroidal anti-inflammatory drug intolerance (acetyl-salicylic acid triad).
Miguel Armengot; Luis Garín; Miguel de Lamo; Francisco Krause; Carmen Carda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of rhinology & allergy     Volume:  24     ISSN:  1945-8932     ISO Abbreviation:  Am J Rhinol Allergy     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-25     Revised Date:  2011-11-10    
Medline Journal Info:
Nlm Unique ID:  101490775     Medline TA:  Am J Rhinol Allergy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-5     Citation Subset:  IM    
Rhinology Unit, General and University Hospital and Medical Center, Valencia, Spain.
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MeSH Terms
Eosinophilia / etiology*
Middle Aged
Nasal Mucosa / pathology*
Nasal Polyps / pathology*

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