Document Detail

Cytological significance of abnormal squamous cells in urinary cytology.
MedLine Citation:
PMID:  21309015     Owner:  NLM     Status:  Publisher    
The aim of this study was to evaluate the significance of abnormal squamous cells (ASCs) in urinary cytology to clarify whether finding of ASCs could improve diagnostic accuracy. A total of 3,812 urine specimens were reviewed. We focused on three parameters of ASCs, necrotic debris, and ASC clusters, and linked them to histological diagnosis and clinical information. ASCs were identified in 34 (0.9%) specimens from 21 different patients. The incidence of ASCs was higher in females than in males. The 34 urine specimens were categorized as voided urine (16 cases), bladder-catheterized urine (17 cases), and bladder-washed fluid (1 case). Six (28.6%) of 21 patients were histologically diagnosed as having combined urothelial carcinoma and squamous cell carcinoma (SCC). Eight patients (38.1%) were histologically diagnosed as having SCC originating from sites other than the urinary tract; those urine specimens showed ASCs that were likely to have been exfoliated from malignant lesions. Necrotic debris and ASC clusters were identified in 12 specimens (35.3%) from 11 patients and 4 specimens (11.8%) from 4 patients, respectively, from a total of 34 specimens. Our results indicate that a great amount of care is needed for cytological diagnosis when attempting to recognize ASCs in urine specimens because ASCs were identified in not only SCC of the bladder but also in carcinoma or nonmalignant lesions of nonurinary tracts. Necrotic debris was found not only in patients who had malignant bladder tumors but also in those who had malignant lesions in locations other than the bladder. Diagn. Cytopathol. 2011; © 2011 Wiley-Liss, Inc.
Manabu Hattori; Yukari Nishimura; Masumi Toyonaga; Hirokuni Kakinuma; Kazumasa Matsumoto; Makoto Ohbu
Related Documents :
21042955 - Value of combined detection of afu and tch in differential diagnosis between malignant ...
11868075 - Mri characteristics in focal hepatic disease before and after administration of mndpdp:...
14658595 - Assessment of breast lesions using doppler with contrast agents.
15052675 - Resistance index in differential diagnosis of liver lesions by color doppler ultrasonog...
522825 - Histoplasmosis mimicking childhood non-hodgkin lymphoma.
759265 - Colonic tuberculosis diagnosed by colonoscopic biopsy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-9
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  -     ISSN:  1097-0339     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Department of Clinical Cytology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa 252-0373, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fine needle aspiration cytology of insular carcinoma of thyroid.
Next Document:  The mechanism of action of mercury on sperm morphology, ATP content and motility in Perca fluviatili...