Document Detail


Cytologic phenotypes of B-cell acute lymphoblastic leukemia-a single center study.
MedLine Citation:
PMID:  19671939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. Twenty patients with ALL, who had been referred to the Children's Medical Center Hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic profile of these patients. Cytologic analysis of blood and bone marrow samples revealed that the frequency of ALL-L1 was 70%, followed by ALL-L2 and ALL-L3. The onset age of the patients with ALL-L1 was significantly lower than the patients with L2/L3. Severe anemia was significantly detected more in L1 group. Flow cytometic study of bone marrow showed that 10 cases had Pre-B1 ALL and 7 cases had Pre-B2 ALL, while three cases had Pro-B ALL. Comparisons of the characteristics and clinical manifestations among these groups did not show any appreciable difference. There were an increase percentage of CD20+ cells and a decrease CD10+ cells in pre-B2 group in comparison with pre-B1 group. Fifteen patients were in standard risk and five were in high risk. Although standard risk patients were more common in the group of pre-B1, this was not significant. Our results confirm the previous reports indicating heterogeneity of ALL. Immunophenotyping is not the only diagnostic test of importance, while morphological assessment still can be used in the diagnosis and classification of the disease.
Authors:
Asghar Ramyar; Masoud Shafiei; Nima Rezaei; Hossein Asgarian-Omran; Shadi Abdar Esfahani; Kasra Moazzami; Abdolfattah Sarafnejad; Asghar Aghamohammadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of allergy, asthma, and immunology     Volume:  8     ISSN:  1735-1502     ISO Abbreviation:  Iran J Allergy Asthma Immunol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-11-25     Revised Date:  2010-02-02    
Medline Journal Info:
Nlm Unique ID:  101146178     Medline TA:  Iran J Allergy Asthma Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  99-106     Citation Subset:  IM    
Affiliation:
Department of Hematology and Oncology of Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antigens, CD20 / immunology
B-Lymphocyte Subsets / immunology*,  pathology
Child
Child, Preschool
Female
Humans
Immunophenotyping
Male
Neprilysin / immunology
Phenotype
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*,  pathology
Risk Factors
Chemical
Reg. No./Substance:
0/Antigens, CD20; EC 3.4.24.11/Neprilysin

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