| Cytologic findings of spindle cell ductal carcinoma in situ of the breast: a case report. | |
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MedLine Citation:
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PMID: 15966297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ductal carcinoma in situ (DCIS), spindle cell type, is a rare and recently recognized entity in the breast. While the histologic features have been described in detail, no cytologic descriptions exist. We describe the cytologic and corresponding histologic findings in a case of spindle cell DCIS. CASE: A 35-year-old woman underwent fine needle aspiration (FNA) of a 1.5-cm, palpable mass. The aspirate showed predominantly clusters and a smaller population of single cells in a necrotic background. The cells were mostly spindled, The cells were mostly spindled, with a minor population of epithelioid cells. They had a high nuclear/cytoplasmic ratio, with hyperchromatic and pleomorphic nuclei that contained prominent nucleoli, altogether diagnostic of malignancy. Given the biphasic cell composition, a diagnosis of metaplastic carcinoma was favored and excision recommended; it showed spindle cell DCIS. CONCLUSION: The cytologic features of spindle cell DCIS and metaplastic spindle cell carcinoma are similar and almost indistinguishable. Despite its rarity, spindle cell DCIS should be considered in the differential diagnosis of biphasic and spindle cell lesions in the breast. |
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Authors:
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Shabnam jaffer; Patrick Emanuel; David Burstein; Alisan Goldfarb |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta cytologica Volume: 49 ISSN: 0001-5547 ISO Abbreviation: Acta Cytol. Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-06-21 Completed Date: 2005-07-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370307 Medline TA: Acta Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 323-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Box 1194, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, usa. shabnam.jaffer@msnyuhealth.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy, Fine-Needle Breast Neoplasms / diagnosis, pathology* Carcinoma / pathology Carcinoma, Intraductal, Noninfiltrating / pathology* Female Humans |
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