Document Detail

Cytologic features of mycobacterial pleuritis: logistic regression and statistical analysis of a blinded, case-controlled study.
MedLine Citation:
PMID:  9740989     Owner:  NLM     Status:  MEDLINE    
Tuberculous pleural effusions are characterized by lymphocytosis; the significance of mesothelial cells is uncertain, as are the cytologic features in concurrent human immunodeficiency virus (HIV) infection. This blinded study compared 38 culture-positive pleural fluids (6 HIV+) with 38 controls from benign exudative processes. Logistic regression analysis selected mature lymphocytes as most predictive of positive culture, and mesothelial cells and eosinophils as negative predictors. Mesothelial cells were scant (< 10% of nucleated cells) in 36/38 cases with mycobacteria (sensitivity 95%); if these cell were > 10%, tuberculosis was virtually ruled out in HIV- patients. Specificity was maximized (82%) when mesothelial cells < 10% were combined with lymphocytes > 50%; positive predictive value with this combination was 76%, but was raised to 96% if moderate/marked cellularity was also identified. Among tuberculosis cases, reactive mesothelial cells differentiated HIV+ from HIV- patients; there was no other significant difference.
E Ellison; P Lapuerta; S E Martin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  19     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  IM; X    
Department of Pathology, University of Southern California, Los Angeles 90033, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications,  epidemiology,  pathology
Case-Control Studies
Cytodiagnosis / statistics & numerical data
Diagnosis, Differential
Epithelium / microbiology,  pathology
Logistic Models
Lymphocytosis / diagnosis*,  epidemiology
Mycobacterium tuberculosis / growth & development,  isolation & purification
Pleural Effusion / microbiology
Retrospective Studies
Sensitivity and Specificity
Single-Blind Method
Tuberculosis, Pleural / complications,  diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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