Document Detail


Cytologic features of low-grade squamous intraepithelial lesion in thinprep papanicolaou test slides and conventional smears: comparison of cases that performed poorly with those that performed well in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology.
MedLine Citation:
PMID:  15628904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Both conventional and ThinPrep Papanicolaou smears with high-grade squamous intraepithelial lesions that are frequently missed are known to have relatively few abnormal cells. Whether this is also true of cases of low-grade squamous intraepithelial lesion is not known. OBJECTIVE: To compare the cytologic features of cases of low-grade squamous intraepithelial lesion that perform poorly with the features of cases that perform well. DESIGN: The cytologic features of 10 ThinPrep Pap Test and conventional smear cases of low-grade squamous intraepithelial lesion that performed poorly in the College of American Pathologists Interlaboratory Comparison Program were compared with 46 ThinPrep Pap Test and conventional smear cases that performed extremely well. The numbers of abnormal cells were categorized into less than 50, 51 to 100, 101 to 250, 251 to 500, and more than 500. RESULTS: The median number of abnormal cells for cases that performed poorly was less than 50, whereas the median number of abnormal cells for cases that performed well was between 101 and 250. Overall, cases that performed poorly were significantly more likely to have less than 50, less than 100, and less than 250 abnormal cells than cases that performed well (P < .001, P < .001, and P = .009, respectively). A minority of cases performed well even with very few abnormal cells and groups. The same findings were present when conventional smears and ThinPrep specimens were analyzed separately. CONCLUSIONS: ThinPrep Pap Test cases and conventional smears with a diagnosis of low-grade squamous intraepithelial lesion that perform poorly in this program have significantly fewer abnormal cells than those that perform well. The median number of abnormal cells in cases that performed well is lower than that of comparable high-grade cases in the program.
Authors:
Andrew A Renshaw; Barbara Dubray-Benstein; Jennifer Haja; Jonathan H Hughes;
Related Documents :
1488644 - Evaluating outcome in stroke rehabilitation (quality control and clinical audit).
23539434 - Case report and review of esophageal lichen planus treated with fluticasone.
9987454 - Comparison of thinprep and pap smear in relation to prediction of adenocarcinoma in situ.
15246524 - Comparison of chest radiography and high-resolution computed tomography findings in ear...
6625994 - Acute cerebellar ataxia and hearing loss as initial symptoms of infectious mononucleosis.
24932824 - Metastatic hepatocellular carcinoma presenting as a sphenoid sinus mass and meningeal c...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  129     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Baptist Hospital of Miami, Miami, FL 33176, USA. Andrewr@bhssf.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / diagnosis*
Cervical Intraepithelial Neoplasia / diagnosis*
Cytodiagnosis / standards*
Databases, Factual
Diagnostic Errors*
Female
Gynecology*
Humans
Pathology, Clinical / standards*
Predictive Value of Tests
Retrospective Studies
Uterine Cervical Neoplasms / diagnosis*
Vaginal Smears / standards*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fine-needle aspiration of pulmonary hamartoma: a common source of false-positive diagnoses in the Co...
Next Document:  Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pat...