| Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy. | |
| | |
MedLine Citation:
|
PMID: 14968415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Well-differentiated hepatocellular carcinoma (HCC) in fine-needle aspiration (FNA) biopsy is characterized by trabeculae three or more cells thick wrapped by peripheral endothelium. The authors encountered another pattern that did not fulfill these classic criteria for malignancy yet was proven to be HCC in clinical follow-up. The objective of this study was to characterize the cytologic features of this pattern with histologic correlations. METHODS: Over a period of 6.5 years, 14 of 123 cases (11.4%) of HCC from 428 liver aspirates showed the unusual pattern. Their cytologic features were compared with 14 cases of nonneoplastic liver on FNA smears that were processed with Ultrafast Papanicolaou stain, and their histologic features were compared on cell blocks with hematoxylin and eosin stain and reticulin stain. RESULTS: The unusual type of well differentiated HCC in FNA smears was characterized by numerous, small hepatocytes with minimal nuclear atypia but reduced cytoplasm, grouped together in microacini of five or more cells and microtrabeculae one or more cells thick of irregular thickness with no apparent peripheral endothelium. Transgressing capillaries were found when the smears were inspected carefully. In histology nine cases that were the compact type of HCC, two cases that were the microacinar type of HCC, and three cases that were the microtrabecular type of HCC. All FNAs showed deficient reticulin framework. All 14 cases of nonneoplastic liver aspirate were characterized by the presence of large tissue fragments that were resistant to smearing. CONCLUSIONS: Well differentiated HCC may present as microtrabeculae of irregular thickness one or more cells thick with inapparent peripheral endothelium or as microacini mimicking neuroendocrine carcinoma. |
| | |
Authors:
|
Grace C H Yang; Guang-Yu Yang; Liang-Che Tao |
Related Documents
:
|
9067105 - Are epithelial cells in fat or connective tissue a reliable indicator of tumor invasion... 8575285 - Fine-needle aspiration cytology of ductal adenoma: report of a case associated with a m... 14755755 - Gliosarcoma: cytopathologic characteristics on fine-needle aspiration (fna) and intraop... 12508175 - Percutaneous image-guided fine-needle aspiration of peritoneal lesions. 8732345 - Hyalinizing trabecular carcinoma of thyroid gland. 23223565 - Birt-hogg-dube syndrome: clinicopathological features of the lung. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Cancer Volume: 102 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2004 Feb |
Date Detail:
|
Created Date: 2004-02-17 Completed Date: 2004-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 27-33 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright 2003 American Cancer Society. |
Affiliation:
|
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA. grace.yang@nyu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biopsy, Needle / methods* Carcinoma, Hepatocellular / pathology* Cohort Studies Cytodiagnosis / methods Diagnosis, Differential Female Focal Nodular Hyperplasia / pathology* Hepatocytes / pathology* Humans Immunohistochemistry Liver Neoplasms / pathology* Male Middle Aged Neoplasm Staging Retrospective Studies Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anorectal cytology as a screening tool for anal squamous lesions: cytologic, anoscopic, and histolog...
Next Document: Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specim...