| Cytologic features of clear cell adnexal carcinoma in 3 dogs. | |
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MedLine Citation:
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PMID: 22616740 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Clear cell adnexal carcinoma is a rare cutaneous adnexal neoplasm without definitive apocrine, sebaceous, or follicular differentiation. Differential diagnoses include sebaceous carcinoma, liposarcoma, and balloon cell melanoma. Immunohistochemical analysis, with positive immunoreactivity for pancytokeratin and vimentin, aids in the diagnosis. Cytologic features of clear cell adnexal carcinoma have not been described previously. OBJECTIVE: The aim of this study was to describe cytologic features of canine clear cell adnexal carcinoma. METHODS: Fine-needle aspirates (FNA) obtained prior to biopsy of cutaneous neoplasms with a histologic diagnosis of clear cell adnexal carcinoma confirmed by immunohistochemical analysis were reviewed retrospectively. Slides prepared from FNA had been stained with modified Wright-Giemsa or automated aqueous Romanowsky stain. RESULTS: Of 20 neoplasms diagnosed as clear cell adnexal carcinoma in dogs, FNA of the mass had been performed in 3 cases. Cytologic features were similar and included high cellularity, marked cellular pleomorphism, loose arrangement of neoplastic cells, and a light blue to gray background resulting from streaming of cytoplasm from ruptured cells. Neoplastic cells were oval to polygonal to spindle-shaped with wispy cytoplasmic projections. Cytoplasmic eosinophilic stippling, globular deposits, or pink needle-shaped inclusions were noted. Criteria of malignancy included marked anisocytosis, anisokaryosis and anisonucleoleosis, multinucleation, karyomegaly, macronucleoli, and atypical mitotic figures. CONCLUSIONS: Clear cell adnexal carcinoma should be included in the cytologic differential diagnosis for a canine cutaneous mass even if an epithelial origin is not readily identified owing to lack of characteristic epithelial features, such as highly cohesive cell clusters, evident cell-to-cell junctions, and distinct cytoplasmic edges. |
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Authors:
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Martina Piviani; Melissa D Sánchez; Reema T Patel |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-22 |
Journal Detail:
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Title: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology Volume: - ISSN: 0275-6382 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9880575 Medline TA: Vet Clin Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 American Society for Veterinary Clinical Pathology. |
Affiliation:
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Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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