Document Detail


Cytologic features of adenocarcinoma, not otherwise specified, in conventional smears: comparison of cases that performed poorly with those that performed well in the College of American Pathologists Interlaboratory Comparison Program in cervicovaginal cytology.
MedLine Citation:
PMID:  16390233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Characteristic cytologic features have been identified that distinguish cases that are consistently identified from those that are sometimes missed in the College of American Pathologists Gynecologic Cytology Program for a variety of different lesions and preparations. OBJECTIVES: To compare the cytologic features of cases of adenocarcinoma, not otherwise specified (NOS), in conventional smears that perform poorly and well. DESIGN: The cytologic features of 21 conventional smear cases of adenocarcinoma, NOS, that performed poorly in the College of American Pathologists Interlaboratory Comparison Program were compared with 17 cases that performed extremely well. RESULTS: Cases that performed well were significantly more likely to have greater than 1000 abnormal cells (P = .006), greater than 100 large abnormal cells (P = .006), large nuclei (P < .001), marked nuclear atypia (P = .02), and hyperchromasia (P = .02). Repair-like features were rare in both groups and were not significant (P = .71). CONCLUSION: Conventional smears with a diagnosis of adenocarcinoma that were consistently identified were significantly more likely to have more abnormal cells, larger abnormal cells, larger nuclei, marked atypia, and hyperchromasia than cases that performed poorly.
Authors:
Andrew A Renshaw; Mary R Schwartz; Edward Wang; Jennifer Haja; Jonathan H Hughes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  130     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Baptist Hospital of Miami, Miami, FL 33176-2197, USA. andrewr@bhssf.org
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / classification,  pathology*
Diagnosis, Differential
Diagnostic Errors / prevention & control*
Female
Humans
North America
Pathology, Clinical / methods,  standards*
Quality Assurance, Health Care
Quality Control
Reproducibility of Results
Societies, Medical
Uterine Cervical Neoplasms / classification,  pathology*
Vaginal Smears / classification,  methods,  standards*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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