Document Detail

Cytologic diagnosis of vaginal papillary squamotransitional cell carcinoma. A case report.
MedLine Citation:
PMID:  11393087     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Papillary squamous and squamotransitional cell carcinomas of the cervix and vagina are infrequent morphologic variants of squamous cell carcinoma that may be underdiagnosed due to a bland histologic appearance. To our knowledge, this entity has not been previously detected by Pap smear evaluation. CASE: Vaginal wall pap smears were collected from a patient with a previous hysterectomy for microinvasive cervicovaginal squamous cell carcinoma and extensive carcinoma in situ. The smears were characterized by: (1) large, darkly staining, three-dimensional, branching, papillary epithelial fragments with prominent fibrovascular cores and lined with loosely cohesive epithelial cells; (2) a highly cellular background population of dissociated single epithelial cells with features of severe dysplasia, including hyperchromatic, coarse chromatin; scant, delicate, frayed cytoplasm and karyorrhectic debris; (3) syncytial aggregates of severely dysplastic epithelial cells morphologically similar to the single cells; and (4) lack of a recognizable, morphologically distinct "transitional cell" population. CONCLUSION: Papillary squamotransitional cell carcinoma of the vagina is a rare morphologic variant of squamous cell carcinoma that should be distinguished from benign vaginal squamous papillomas, condylomatous lesions and verrucous carcinoma. However, this lesion is also related to human papillomavirus infection, particularly the high-risk types. Papillary squamotransitional cell carcinoma can be suspected on Pap smear when high grade squamous intraepithelial lesion features are found in combination with three-dimensional papillary tissue fragments with prominent fibrovascular cores.
Z Vesoulis; C A Erhardt
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  45     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-9     Citation Subset:  IM    
Department of Cytopathology, Summa Health Systems, 525 East Market Street, Akron, Ohio 44304, USA.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Condylomata Acuminata / pathology
Diagnosis, Differential
Middle Aged
Papilloma / pathology
Vaginal Neoplasms / pathology*
Vaginal Smears*

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