Document Detail

Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China.
MedLine Citation:
PMID:  18323271     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Esophageal squamous cell carcinoma (ESCC) is associated with very high regional mortality rates in several countries. Our initial test of esophageal cytology screening devices found them not sensitive enough for an early detection program. The current study tested a newly designed "mechanical" balloon and a traditional Chinese inflatable balloon, followed by liquid-based cytology, to detect biopsy-proven squamous dysplasia and early cancer. STUDY DESIGN: Participants were randomized to a cytologic sampler, followed by endoscopy with iodine staining. For each patient, the cytologic diagnosis (test) was compared with the worst endoscopic biopsy diagnosis (truth). RESULTS: Seven hundred forty subjects completed both examinations. Approximately 30% showed atypical squamous cells of undetermined significance (ASCUS), and 10% showed squamous intraepithelial lesions. Seven hundred twenty-five subjects (98%) had satisfactory biopsies, and 32% had low grade dysplasia or worse disease. Defining > ASCUS, favor neoplastic, as a positive screening test, the sensitivities/specificities of the mechanical and inflatable balloons were 39%/85% and 46%/84%, respectively, for detecting any squamous dysplasia or cancer. CONCLUSION: These esophageal cell samplers performed equivalently, but the accuracy was still too low for a primary screening test. These results highlight the need to develop new cytologic criteria or molecular markers that can better detect early squamous esophageal disease [corrected]
Qin-Jing Pan; Mark J Roth; Hui-Qin Guo; Michael L Kochman; Guo-Qing Wang; Michael Henry; Wen-Qiang Wei; Carol A Giffen; Ning Lu; Christian C Abnet; Chang-Qing Hao; Philip R Taylor; You-Lin Qiao; Sanford M Dawsey
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cytologica     Volume:  52     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-04-29     Revised Date:  2008-05-27    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-23     Citation Subset:  IM    
Department of Cytology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
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MeSH Terms
Carcinoma, Squamous Cell / diagnosis*,  epidemiology,  pathology
China / epidemiology
Cytological Techniques
Esophageal Neoplasms / diagnosis*,  epidemiology,  pathology
Middle Aged
Precancerous Conditions / diagnosis*,  epidemiology,  pathology
Grant Support
Erratum In:
Acta Cytol. 2008 Mar-Apr;52(2):276

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