Document Detail

Cytologic correlates of chemical carcinogens in respiratory tracts of dogs.
MedLine Citation:
PMID:  280708     Owner:  NLM     Status:  MEDLINE    
During canine respiratory carcinogenesis studies with benzo[a]pyrene (BP) and N-methyl-N-nitrosourea (NMU), a stereotypic pattern of cytomorphology characteristic for each carcinogen was observed. In the early stage, BP induced changes primarily in the cytoplasm. These changes consisted of incresaed size, basophilia, and vacuolization. In contrast, NMU induced primarily nuclear enlargement and enhanced the prominence of the nucleolus. Subsequently, cells exposed to BP demonstrated pleomorphism of the cytoplasm and nucleus, whereas cells exposed to NMU formed bizarre spindle-shaped cells. Cells were generally more scattered from one another following BP treatment than after NMU treatment. When the mucosa was exposed to NMU after the previous use of BP, the cytologic findings promptly became those characteristic of NMU.
K Matsumura; A H Cohen; E C Shors; J R Benfield
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  61     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1209-14     Citation Subset:  IM    
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MeSH Terms
Cell Nucleolus / ultrastructure
Cell Nucleus / ultrastructure
Cytoplasm / ultrastructure
Epithelium / pathology
Lung Neoplasms / chemically induced,  pathology*
Metaplasia / pathology
Neoplasms, Experimental / pathology*
Nitrosourea Compounds*
Precancerous Conditions / chemically induced,  pathology*
Time Factors
Reg. No./Substance:
0/Benzopyrenes; 0/Nitrosourea Compounds; 684-93-5/Methylnitrosourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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