| Cytologic correlates of chemical carcinogens in respiratory tracts of dogs. | |
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MedLine Citation:
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PMID: 280708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During canine respiratory carcinogenesis studies with benzo[a]pyrene (BP) and N-methyl-N-nitrosourea (NMU), a stereotypic pattern of cytomorphology characteristic for each carcinogen was observed. In the early stage, BP induced changes primarily in the cytoplasm. These changes consisted of incresaed size, basophilia, and vacuolization. In contrast, NMU induced primarily nuclear enlargement and enhanced the prominence of the nucleolus. Subsequently, cells exposed to BP demonstrated pleomorphism of the cytoplasm and nucleus, whereas cells exposed to NMU formed bizarre spindle-shaped cells. Cells were generally more scattered from one another following BP treatment than after NMU treatment. When the mucosa was exposed to NMU after the previous use of BP, the cytologic findings promptly became those characteristic of NMU. |
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Authors:
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K Matsumura; A H Cohen; E C Shors; J R Benfield |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 61 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-01-24 Completed Date: 1979-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzopyrenes* Cell Nucleolus / ultrastructure Cell Nucleus / ultrastructure Cytodiagnosis Cytoplasm / ultrastructure Dogs Epithelium / pathology Lung Neoplasms / chemically induced, pathology* Metaplasia / pathology Methylnitrosourea* Neoplasms, Experimental / pathology* Nitrosourea Compounds* Precancerous Conditions / chemically induced, pathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrenes; 0/Nitrosourea Compounds; 684-93-5/Methylnitrosourea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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