| Cytologic characteristics of abnormal cells in prior "normal" cervical/vaginal Papanicolaou smears from women with a high grade squamous intraepithelial lesion. | |
| | |
MedLine Citation:
|
PMID: 10227594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Some cervical/vaginal Papanicolaou (Pap) smears previously diagnosed as normal in women with a high grade squamous intraepithelial lesion (HSIL) are found to contain abnormal cells on retrospective review. This study characterized and quantitated such cells in 100 Pap smears. METHODS: One hundred prior negative Pap smears from 49 women with a newly diagnosed HSIL were rescreened, as were 107 negative Pap smears from 100 women with normal subsequent smears. Cases were assorted randomly so that the rescreener was unaware of the subsequent follow-up. RESULTS: All 12 Pap smears found to contain atypical mature and immature metaplastic cells belonged to the group with a subsequent HSIL (P = 0.001). In addition, 18 of the 100 previously negative Pap smears (18%) had immature metaplastic cells without nuclear atypia compared with 4 of 107 Pap smears (4%) in the control group (P = 0.0007). CONCLUSIONS: This study supports the observations of other authors that atypical metaplastic cells, especially those of the immature type, are associated with HSIL. These cells most likely are HSIL lesional cells, which are not easily recognizable as such. Immature metaplastic cells without atypia also were shown to be associated significantly with HSIL in this study. These cells may be unrecognizable lesional cells or a marker of increased risk for HSIL and deserve further study. |
| | |
Authors:
|
M A Montes; E S Cibas; S A DiNisco; K R Lee |
Related Documents
:
|
6496064 - Nasal epithelium in woodworkers in the furniture industry. a histological and cytologic... 21429724 - Hexane/ethanol extract of glycyrrhiza uralensis and its active compound isoangustone a ... 6375494 - Automated cytopathologic diagnosis of bronchial carcinoma. ii. preliminary results of c... 9022744 - Differential diagnosis of hürthle cell neoplasms on fine needle aspirates. can we do a... 16600524 - Cell brain: insight into hepatocarcinogenesis. 7948754 - Measurement of cell migration stimulated by interleukin 8: use of atp chemiluminescence. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Cancer Volume: 87 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1999 Apr |
Date Detail:
|
Created Date: 1999-05-12 Completed Date: 1999-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 56-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Squamous Cell
/
diagnosis* Cervical Intraepithelial Neoplasia / diagnosis* Cervix Uteri / cytology, pathology* Cytodiagnosis Female Follow-Up Studies Humans Sensitivity and Specificity Uterine Cervical Neoplasms / diagnosis* Vaginal Smears* |
| Comments/Corrections | |
Comment In:
|
Cancer. 1999 Apr 25;87(2):45-7
[PMID:
10227592
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Utility of liquid-based cytology for cervical carcinoma screening: results of a population-based stu...
Next Document: The use of fine-needle aspiration cytology in the molecular characterization of neuroblastoma in chi...