| Cytologic atypia associated with microglandular hyperplasia. | |
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MedLine Citation:
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PMID: 7924805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it has long been known that microglandular hyperplasia (MGH) may be associated with cytologic atypia in cervical smears, the cytomorphology of MGH has not been described in great detail. To clarify its cytomorphology, Pap smears obtained from biopsy proven cases of MGH over a 3-yr period were reviewed. Of 122 smears containing endocervical cells, 34 (28%) showed striking glandular abnormalities. In two cases, adenocarcinoma and adenocarcinoma in situ were falsely suggested and a high grade squamous intraepithelial lesion (HGSIL-CIN III) was not confirmed in a conization specimen which showed only low grade SIL and MGH. Review of six cytologic diagnoses of HGSIL (CIN III) unconfirmed on biopsy suggested overcalls related to MGH related atypia in five. Cytologic features of MGH, therefore, may occasionally result in erroneous interpretations of HGSIL as well as glandular neoplasia. Although these changes may be striking, comparison with glandular atypia not associated with MGH shows that they are not entirely specific. |
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Authors:
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P T Valente; H D Schantz; M Schultz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diagnostic cytopathology Volume: 10 ISSN: 8755-1039 ISO Abbreviation: Diagn. Cytopathol. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-11-10 Completed Date: 1994-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8506895 Medline TA: Diagn Cytopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 326-31 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Texas Health Science Center at San Antonio 78284-7750. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Cervix Uteri / pathology* Female Follow-Up Studies Humans Hyperplasia / pathology Middle Aged Predictive Value of Tests Vaginal Smears |
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