Document Detail

Cytologic atypia associated with microglandular hyperplasia.
MedLine Citation:
PMID:  7924805     Owner:  NLM     Status:  MEDLINE    
Although it has long been known that microglandular hyperplasia (MGH) may be associated with cytologic atypia in cervical smears, the cytomorphology of MGH has not been described in great detail. To clarify its cytomorphology, Pap smears obtained from biopsy proven cases of MGH over a 3-yr period were reviewed. Of 122 smears containing endocervical cells, 34 (28%) showed striking glandular abnormalities. In two cases, adenocarcinoma and adenocarcinoma in situ were falsely suggested and a high grade squamous intraepithelial lesion (HGSIL-CIN III) was not confirmed in a conization specimen which showed only low grade SIL and MGH. Review of six cytologic diagnoses of HGSIL (CIN III) unconfirmed on biopsy suggested overcalls related to MGH related atypia in five. Cytologic features of MGH, therefore, may occasionally result in erroneous interpretations of HGSIL as well as glandular neoplasia. Although these changes may be striking, comparison with glandular atypia not associated with MGH shows that they are not entirely specific.
P T Valente; H D Schantz; M Schultz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  10     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  326-31     Citation Subset:  IM    
Department of Pathology, University of Texas Health Science Center at San Antonio 78284-7750.
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MeSH Terms
Cervix Uteri / pathology*
Follow-Up Studies
Hyperplasia / pathology
Middle Aged
Predictive Value of Tests
Vaginal Smears

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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