Document Detail

Cytolethal distending toxin generates cell death by inducing a bottleneck in the cell cycle.
MedLine Citation:
PMID:  16427513     Owner:  NLM     Status:  MEDLINE    
Cytolethal distending toxin (CDT) is a bacterial protein that is widely distributed among gram-negative bacteria including Escherichia coli, Campylobacter spp., enterohepatic Helicobacter spp., Actinobacillus actinomycetemcomitans and Haemophilus ducreyi. In vitro studies demonstrated that it is able to stop proliferation of various cell lines. The toxin is composed of three subunits designated CDTs A, B and C. The B subunit targets the eukaryotic DNA and triggers a signalling pathway involving different protein kinases which results in a cell block before entering into mitosis. To date, the individual role of the A and C subunits has not been totally elucidated. There are indications that the CDT is also produced in vivo. Its exact role in pathogenesis is not yet clear, but possible actions include inhibition of epithelial cell proliferation, apoptosis of immune cells and inhibition of a fibrotic response.
Liesbeth M Ceelen; Annemie Decostere; Richard Ducatelle; Freddy Haesebrouck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-06-01
Journal Detail:
Title:  Microbiological research     Volume:  161     ISSN:  0944-5013     ISO Abbreviation:  Microbiol. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437794     Medline TA:  Microbiol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  109-20     Citation Subset:  IM    
Department of Pathology, Bacteriology and Avian diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
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MeSH Terms
Bacterial Toxins* / chemistry,  genetics
Cell Cycle / physiology
Cell Division / physiology
Gram-Negative Bacteria / cytology*,  genetics
Reg. No./Substance:
0/Bacterial Toxins; 0/cytolethal distending toxin

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