| Cytolethal distending toxin generates cell death by inducing a bottleneck in the cell cycle. | |
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MedLine Citation:
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PMID: 16427513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytolethal distending toxin (CDT) is a bacterial protein that is widely distributed among gram-negative bacteria including Escherichia coli, Campylobacter spp., enterohepatic Helicobacter spp., Actinobacillus actinomycetemcomitans and Haemophilus ducreyi. In vitro studies demonstrated that it is able to stop proliferation of various cell lines. The toxin is composed of three subunits designated CDTs A, B and C. The B subunit targets the eukaryotic DNA and triggers a signalling pathway involving different protein kinases which results in a cell block before entering into mitosis. To date, the individual role of the A and C subunits has not been totally elucidated. There are indications that the CDT is also produced in vivo. Its exact role in pathogenesis is not yet clear, but possible actions include inhibition of epithelial cell proliferation, apoptosis of immune cells and inhibition of a fibrotic response. |
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Authors:
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Liesbeth M Ceelen; Annemie Decostere; Richard Ducatelle; Freddy Haesebrouck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2005-06-01 |
Journal Detail:
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Title: Microbiological research Volume: 161 ISSN: 0944-5013 ISO Abbreviation: Microbiol. Res. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437794 Medline TA: Microbiol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 109-20 Citation Subset: IM |
Affiliation:
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Department of Pathology, Bacteriology and Avian diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. liesbeth.ceelen@UGent.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Toxins*
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chemistry,
genetics Cell Cycle / physiology Cell Division / physiology Gram-Negative Bacteria / cytology*, genetics Humans |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/cytolethal distending toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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