Document Detail

Cytokines and myocardial dysfunction: state of the art.
MedLine Citation:
PMID:  18226775     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Myocardial dysfunction has been associated with inflammation and cytokine modulation. OBJECTIVES: The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction. METHODS: Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research. RESULTS: For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time. CONCLUSION: Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.
Ayman A El-Menyar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  14     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-74     Citation Subset:  IM    
Weill Cornell Faculty of Medicine, Doha, Qatar.
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MeSH Terms
Biological Markers / blood
Cardiomyopathies / drug therapy*,  mortality,  physiopathology*
Cardiotonic Agents / therapeutic use*
Cytokines / blood*
Heart Failure / drug therapy*,  mortality,  physiopathology*
Interleukin-10 / blood
Interleukin-6 / blood
Randomized Controlled Trials as Topic
Sensitivity and Specificity
Severity of Illness Index
Survival Analysis
Treatment Outcome
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/Biological Markers; 0/Cardiotonic Agents; 0/Cytokines; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

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