| Cytokines and irritable bowel syndrome: Where do we stand? | |
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MedLine Citation:
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PMID: 22178716 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, which presents with one or more gastrointestinal symptoms without any structural or organic abnormality. The etiology and pathophysiological mechanisms of IBS remain uncertain. Residual or reactivated inflammation at the molecular level is considered the underlying mechanism of post-infectious IBS. On the other hand, genetic variations in the immunological components of the body, including cytokine gene polymorphisms, are proposed as a potential mechanism of IBS even in patients without previous gastrointestinal infection. Several studies have suggested imbalanced cytokine signaling as an etiology for IBS. In this review, recent findings on cytokine profiles and cytokine gene polymorphisms in patients with IBS are described and the role of cytokines in animal models of IBS is discussed. |
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Authors:
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Mohammad Bashashati; Nima Rezaei; Christopher N Andrews; Chun-Qiu Chen; Nasser Ebrahimi Daryani; Keith A Sharkey; Martin A Storr |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Cytokine Volume: - ISSN: 1096-0023 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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