Document Detail


Cytokines in patients with ischaemic heart disease or myocardial infarction.
MedLine Citation:
PMID:  14560325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cytokines are responsible for the modulation of immunological and inflammatory processes as well as proliferative responses and apoptosis. It has been recently suggested that such cytokines as interleukin 6 (IL-6), soluble interleukin 6 receptor (sIL-6R) and anti-inflammatory cytokines such as interleukin 10 (IL-10) may play a significant role in the pathogenesis of acute coronary syndromes. AIM: To assess serum concentration of IL-6, sIL-6R and IL-10 in patients with ischaemic heart disease or acute myocardial infarction (AMI). METHODS: The study group consisted of 74 patients (25 females, 49 males, aged 40-69 years) divided into three groups; group I - 18 patients with AMI (up to 12 hours from the onset of symptoms), group II - 31 patients with unstable angina and group III - 25 patients with stable angina. The control group consisted of 20 healthy subjects. RESULTS: The IL-6 and sIL-6R serum levels were significantly higher in patients from groups I and II compared with patients from group III and controls, whereas the IL-10 serum concentration was similar in all studied groups. In patients with acute coronary syndromes serum concentrations of examined cytokines were positively correlated with acute inflammatory phase parameters and classical risk factors such as body mass index, blood pressure and lipid levels. CONCLUSIONS: IL-6 and sIL-6R are markers of acute coronary syndromes and may be used for the identification of high-risk patients with unstable angina or AMI.
Authors:
Anna Bossowska; Beata Kiersnowska-Rogowska; Artur Bossowski; Bogdan Galar; Piotr Sowiński
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  59     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-15     Completed Date:  2004-03-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  105-14     Citation Subset:  IM    
Affiliation:
SP ZOZ MSWiA, Białystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / blood*,  diagnosis,  immunology
Angina, Unstable / blood*,  diagnosis,  immunology
Biological Markers / blood
Diagnostic Techniques, Cardiovascular
Female
Humans
Interleukin-10 / blood*
Interleukin-6 / blood*
Male
Middle Aged
Myocardial Infarction / blood*,  diagnosis,  immunology
Predictive Value of Tests
Receptors, Interleukin-6 / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Receptors, Interleukin-6; 130068-27-8/Interleukin-10

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