Document Detail

Cytokines in chronically critically ill patients after activity and rest.
MedLine Citation:
PMID:  17456587     Owner:  NLM     Status:  MEDLINE    
Inflammation, a common problem for patients in the intensive care unit (ICU), frequently is associated with serious and prolonged critical illnesses. To date, no study has examined whether physical activity influences inflammatory factors in critically ill adults. The objectives of this study were to (a) examine the relationships between type and duration of physical activity and serum levels of interleukin 6 (IL-6), a proinflammatory cytokine; IL-10, an anti-inflammatory cytokine; and their ratio and (b) determine if there are associations between cytokines or their ratio and activity or outcomes. This descriptive feasibility study investigated the approaches to measuring levels of physical activity and its relationship to serum levels of IL-6 and IL-10 and the ratio between them in patients with prolonged mechanical ventilation during periods of activity and rest. Measurements included serum IL-6 and IL-10 levels, direct observation and actigraphy, and prospective chart review. Ten critically ill patients who were mechanically ventilated for an average of 10 days in a large, urban, teaching hospital were enrolled. The average ratio of IL-6 to IL-10 improved after an average of 14.7 min of passive physical activity, typically multiple in-bed turns associated with hygiene. IL-6, IL-10, and their ratio were not associated with patient outcomes of weaning success or length of stay. High levels of IL-6 were associated with mortality. Cytokine balance may be improved by low levels of activity among patients with prolonged critical illness. The pattern of cytokines produced after activity may improve patients' recovery from prolonged critical illness and mechanical ventilation.
Chris Winkelman; Patricia A Higgins; Yea Jyh Kathy Chen; Alan D Levine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Biological research for nursing     Volume:  8     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-05-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-71     Citation Subset:  IM; N    
Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio 44118-3601, USA.
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MeSH Terms
Bed Rest / adverse effects
Biological Markers / blood
Chronic Disease*
Clinical Nursing Research
Critical Illness*
Feasibility Studies
Interleukin-10 / blood*,  immunology
Interleukin-6 / blood*,  immunology
Length of Stay / statistics & numerical data
Middle Aged
Midwestern United States
Motor Activity / physiology*
Outcome Assessment (Health Care)
Patient Discharge / statistics & numerical data
Pilot Projects
Prospective Studies
Range of Motion, Articular / physiology
Respiration, Artificial / adverse effects
Rest / physiology*
Time Factors
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 130068-27-8/Interleukin-10

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