| Cytokines and cytokine receptors in acute lymphoblastic leukemia expressing myeloid markers--role in growth regulation. | |
| | |
MedLine Citation:
|
PMID: 7873998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is no evidence that cancer cells including leukemic cells are immortal. It has been clearly indicated that certain cytokines can significantly stimulate leukemic cell proliferation in vitro, and sustain the circuit of autocrine or paracrine stimulation. The biological roles of cytokines and cytokine receptors have been intensively investigated in acute leukemia. Recently coexpression of both lymphoid and myeloid features on a single leukemic cell has been well recognized using a flowcytometric technique. Studies of ALL cells expressing myeloid markers (My+ ALL) have indicated that the profiles of cytokines and cytokine receptors expressed by My+ ALL show both similarities and differences to those in My- ALL or acute myelogenous leukemia (AML), suggesting that My+ ALL cells may originate from uncommitted hematopoietic precursor cells coexpressing features of both lymphoid and myeloid lineages. The exact assessment of cytokine response of leukemic cells would provide an important tool for phenotyping acute leukemia based on the growth properties of the cells (cytokine phenotyping), in addition to the morphologic classification and immunological surface phenotyping. Additionally alteration of sensitivity to cytotoxic anticancer drugs by cytokine stimulation may be the new strategy for biologic therapy of acute leukemia. |
| | |
Authors:
|
Y Komada; M Sakurai |
Related Documents
:
|
20471678 - Gemtuzumab ozogamicin (mylotarg) upregulates tissue factor expression but not secretion... 7593128 - Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in... 229598 - Ultrastructural study of leukemic cell phagocytosis using the myeloperoxidase reaction. 10490738 - Relapse after allogeneic bmt for chronic myeloid leukemia (cml) may be sustained by a s... 17464188 - The present status of cell tracking methods in animal models using magnetic resonance i... 21576928 - Immunosenescence of human natural killer cells. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Leukemia & lymphoma Volume: 15 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1994 Nov |
Date Detail:
|
Created Date: 1995-04-06 Completed Date: 1995-04-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 411-8 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Mie University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, Surface
/
analysis* Antineoplastic Agents / administration & dosage Cell Division Colony-Stimulating Factors / physiology Cytokines / physiology*, therapeutic use Flow Cytometry Hematopoietic Stem Cells / pathology Humans Immunophenotyping Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*, therapy Receptors, Cytokine / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Surface; 0/Antineoplastic Agents; 0/Colony-Stimulating Factors; 0/Cytokines; 0/Receptors, Cytokine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of human recombination activating genes (RAG-1 and RAG-2) in lymphoma.
Next Document: The hematopoietic stem cell transplantation in Hodgkin's disease: questions and controversies.