Document Detail


Cytokines and chemokines orchestrate atopic skin inflammation.
MedLine Citation:
PMID:  16815153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
Authors:
Bernhard Homey; Martin Steinhoff; Thomas Ruzicka; Donald Y M Leung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  118     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-89     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany. Bernhard.Homey@uni-duesseldorf.de
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MeSH Terms
Descriptor/Qualifier:
Cell Movement
Chemokines / physiology*
Cytokines / physiology*
Dendritic Cells / physiology
Dermatitis, Atopic / etiology*,  immunology
Eosinophils / immunology
Humans
Immunity, Innate
Immunologic Memory
Leukocytes / immunology
Lymphocyte Activation
Skin / immunology
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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