Document Detail


Cytokines and chemokines in viral encephalitis: a clinicoradiological correlation.
MedLine Citation:
PMID:  20153811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Japanese encephalitis (JE) is the commonest encephalitis in South East Asia associated with high morbidity and mortality. Neuronal injury is attributed to a number of proinflammatory cytokines. This study evaluates cerebrospinal fluid (CSF) cytokines and chemokines in encephalitis and correlates these with clinical and magnetic resonance imaging (MRI) findings. We examined 14 patients with encephalitis (8 JE, 1 dengue, 5 nonspecific encephalitis) and 10 healthy controls. CSF cytokines (IL-1beta, IL-6, IL-10, IL-12p70, TNF-alpha, IL-8) and chemokines (IP-10, MCP-1, MIG, IL-8 and RANTES) were estimated using Cytometric Bead Array, compared with controls and were correlated with severity of encephalitis, radiological findings and presence of movement disorders. Median age of the patients was 25.5 (range 6-55 years); 6 had seizures, 10 movement disorders and 6 out of 11 had MRI abnormalities. The MRI abnormalities included thalamic involvement in 5, basal ganglia and mid brain in 3 each and cortical involvement in 2 patients. Both the patients with cortical involvement had seizures and 5 of the 10 patients with movement disorders had thalamic, basal ganglia and/or mid brain involvement. There was significant increase in IL-6 (p=0.01), RANTES (p=0.02) and IL-8 (p=0.02) in encephalitis compared to controls but there was no difference in IL12p70, TNF-alpha, IL-10, IL-1beta and MCP-1. Cytokines and chemokines did not correlate with severity of encephalitis, radiological changes and presence of movement disorders. CSF IL-6, IL-8 and RANTES were significantly higher in encephalitis patients compared to controls.
Authors:
Jayantee Kalita; Ruchi Srivastava; Manoj Kumar Mishra; Anirban Basu; Usha Kant Misra
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-12
Journal Detail:
Title:  Neuroscience letters     Volume:  473     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  48-51     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chemokines / cerebrospinal fluid
Child
Cytokines / cerebrospinal fluid*
Dengue / cerebrospinal fluid,  pathology,  physiopathology
Encephalitis, Japanese / cerebrospinal fluid,  pathology,  physiopathology
Encephalitis, Viral / cerebrospinal fluid*,  pathology*,  physiopathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Young Adult
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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