| Cytokines and brain excitability. | |
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MedLine Citation:
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PMID: 22214786 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and neurons in the central nervous system. Peripheral or central inflammation is characterized by an upregulation of cytokines and their receptors in the brain. Emerging evidence indicates that pro-inflammatory cytokines modulate brain excitability. Findings from both the clinical literature and from in vivo and in vitro laboratory studies suggest that cytokines can increase seizure susceptibility and may be involved in epileptogenesis. Cellular mechanisms that underlie these effects include upregulation of excitatory glutamatergic transmission and downregulation of inhibitory GABAergic transmission. |
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Authors:
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Michael A Galic; Kiarash Riazi; Quentin J Pittman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-27 |
Journal Detail:
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Title: Frontiers in neuroendocrinology Volume: - ISSN: 1095-6808 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513292 Medline TA: Front Neuroendocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Hotchkiss Brain Institute, Snyder Institute of Infection, Immunity and Inflammation, and Alberta Children's Hospital Research Institute, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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