Document Detail


Cytokines and brain excitability.
MedLine Citation:
PMID:  22214786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and neurons in the central nervous system. Peripheral or central inflammation is characterized by an upregulation of cytokines and their receptors in the brain. Emerging evidence indicates that pro-inflammatory cytokines modulate brain excitability. Findings from both the clinical literature and from in vivo and in vitro laboratory studies suggest that cytokines can increase seizure susceptibility and may be involved in epileptogenesis. Cellular mechanisms that underlie these effects include upregulation of excitatory glutamatergic transmission and downregulation of inhibitory GABAergic transmission.
Authors:
Michael A Galic; Kiarash Riazi; Quentin J Pittman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-27
Journal Detail:
Title:  Frontiers in neuroendocrinology     Volume:  33     ISSN:  1095-6808     ISO Abbreviation:  Front Neuroendocrinol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-06-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7513292     Medline TA:  Front Neuroendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1.
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MeSH Terms
Descriptor/Qualifier:
Akathisia, Drug-Induced
Animals
Brain / metabolism*
Cytokines / physiology*
Down-Regulation
Epilepsy / physiopathology
Humans
Inflammation / physiopathology
Neurons / drug effects,  physiology*
Psychomotor Agitation / etiology*
Seizures / immunology
Synaptic Transmission / drug effects*
Up-Regulation
gamma-Aminobutyric Acid / physiology
Grant Support
ID/Acronym/Agency:
67143//Canadian Institutes of Health Research; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Cytokines; 56-12-2/gamma-Aminobutyric Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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