Document Detail

Cytokines, bone turnover markers and weight change in candidates for lung transplantation.
MedLine Citation:
PMID:  17419084     Owner:  NLM     Status:  MEDLINE    
Weight loss in chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and may negatively affect bone mineral density. Increased serum levels of cytokines such as tumour necrosis factor (TNF)-alpha have been associated with weight loss and with bone resorption. We studied the association between systemic inflammation, markers for bone turnover and recent weight change in underweight (n=48) and normal-weight patients (n=23) candidates for lung transplantation where the majority (56%) had COPD. Osteoporosis or osteopenia was present in all the diagnostic groups. The resulting model of linear regression in COPD patients showed that for the 1-CTP (a marker of bone resorption) model, the total variation of 61% was explained by recent weight change, sTNF-alpha receptor(R)II, dose of prednisolon and age. The resulting model of linear regression in the whole group of patients showed that the total variation of 72% was explained by recent weight change, sTNF-alpha RI, diagnosis (COPD/other diagnosis), dose of prednisolon and C-reactive protein. In conclusion, our results showed that serum concentration of 1-CTP was positively associated with sTNF-alpha receptor II and negatively with recent weight change in patients with advanced COPD. Recent weight loss in both the underweight and normal-weight patients showed to be a more important contributor than recent weight loss only in underweight patients for explaining variations in 1-CTP.
L Førli; O J Mellbye; J Halse; O Bjørtuft; M Vatn; J Boe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-24
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  21     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  IM    
Department of Medicine, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway. <>
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MeSH Terms
Anti-Inflammatory Agents / adverse effects
Biological Markers / blood
Body Weight*
Bone Density*
Bone Diseases, Metabolic / physiopathology
C-Reactive Protein / analysis
Cross-Sectional Studies
Cytokines / blood*
Lung Diseases, Interstitial / physiopathology*
Lung Transplantation*
Middle Aged
Prednisolone / adverse effects
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biological Markers; 0/Cytokines; 50-24-8/Prednisolone; 9007-41-4/C-Reactive Protein

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