| Cytokines as important playmakers of experimental hepatocarcinogenesis confounded by diabetes. | |
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MedLine Citation:
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PMID: 22166570 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose. To explore the possible intermediary pathways through which diabetes mellitus (DM) adversely worsens hepatocellular carcinoma (HCC), focusing on cell life controllers as some transcription factors and inflammatory mediators. Material and methods. Forty male albino rats were divided into four groups, control, cancer [given single intra-peritoneal (IP) dose of diethyl nitrosamine, NDEA, 125 mg/kg body weight], diabetic (given single dose of streptozotocin, STZ, 65 mg/kg) and cancer diabetic. HCC was initiated with NDEA, 3 weeks later, DM was induced with STZ. At 14th week, animals were sacrificed. Serum ALT, AST, GGT activities, AFP, IL-6, TNF-α levels and liver tissue Bax and Bcl2 proteins were measured. Liver sections were stained for histological examination. Both histological and AFP variations were chosen to prove cancer development. Results. NDEA group showed significant increase in liver weight, serum ALT, AST, GGT, AFP, TNF-α, IL-6 and liver Bcl2 protein with decrease in total body weight, liver Bax protein and Bax/Bcl2 ratio. These effects were more pronounced in DENA plus STZ group. IL-6, TNF-α and Bcl2 were positively correlated while Bax and Bax/Bcl2 ratio were negatively correlated to AFP levels reflecting potential diagnostic value. Conclusion. Co-induction of DM in the course of hepatocarcinogenesis can dramatically influence disease progression through inflammation and retarded apoptosis. The suggested apoptotic and inflammatory markers seem to be beneficial diagnostic tools for HCC and improve the diagnostic performance of AFP. |
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Authors:
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Nabil M Abdel-Hamid; Maiiada H Nazmy; Manal I Abdel-Ghany; Walaa H Nazmy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of hepatology : official journal of the Mexican Association of Hepatology Volume: 11 ISSN: 1665-2681 ISO Abbreviation: Ann Hepatol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155885 Medline TA: Ann Hepatol Country: Mexico |
Other Details:
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Languages: eng Pagination: 118-27 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Faculty of Pharmacy, Minia University, Egypt;Diagnostic Laboratory. Abtal El-Faluga Street Mit-Gomre, Dakahlia, Egypt E-mail: nabilmohie@yahoo.com. |
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