| Cytokines and the aging brain - what we don't know might help us. | |
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MedLine Citation:
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PMID: 15374674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cognitive aspects of aging represent a grave challenge for our societal circumstances as members of the baby-boom generation spiral toward a collective 'senior moment'. In addition, age-related changes in the CNS can contribute to motor deficits and other somatic aberrations. Inflammation and its regulation by cytokines have been connected to many aspects of aging, and mechanisms addressed here provide a rationale for this. Nevertheless, a role for cytokines in normal aging of the human brain has not been confirmed, and it seems to be possible to ameliorate both cognitive decline and cytokine elevation via lifestyle choices. So ignorance of the brain should not prohibit development of successful strategies for delaying or avoiding neurological deficits. |
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Authors:
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Angela M Bodles; Steven W Barger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Trends in neurosciences Volume: 27 ISSN: 0166-2236 ISO Abbreviation: Trends Neurosci. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-17 Completed Date: 2004-11-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 621-6 Citation Subset: IM |
Affiliation:
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Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Aging / metabolism* Animals Brain / physiopathology* Cognition* Cytokines / metabolism* Humans Inflammation / complications, metabolism* Neurodegenerative Diseases / etiology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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P01AG12411/AG/NIA NIH HHS; R01AG17498/AG/NIA NIH HHS; R01HD037989/HD/NICHD NIH HHS; R01NS046439/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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