| Cytokines and their STATs in cutaneous and visceral leishmaniasis. | |
| | |
MedLine Citation:
|
PMID: 20300429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cytokines play a critical role in shaping the host immune response to Leishmania infection and directing the development of protective and non-protective immunities during infection. Cytokines exert their biological activities through the activation and translocation of transcription factors into the nucleus whether they drive the expression of specific cytokine-responsive genes. Signal transducer and activator of transcription (STATs) are transcription factors which play a critical role in mediating signaling downstream of cytokine receptors and are important for shaping the host immune response during Leishmania infection. Here we discuss the signature cytokines and their associated STATs involved in the host immune response during cutaneous and visceral leishmaniasis. |
| | |
Authors:
|
Hannah E Cummings; Rashmi Tuladhar; Abhay R Satoskar |
Related Documents
:
|
12654849 - Th2 responses predominate during the early phases of infection in patients with localiz... 16281989 - Subversion of host cell signalling by the protozoan parasite leishmania. 15811879 - Arginase and polyamine synthesis are key factors in the regulation of experimental leis... 10688819 - Leishmania donovani infection of bone marrow stromal macrophages selectively enhances m... 20038619 - Early curative applications of the aminoglycoside wr279396 on an experimental leishmani... 8480859 - Development of in vitro parameters of cell-mediated immunity in the course of human cut... 11159009 - Neutrophils induce apoptosis of lung epithelial cells via release of soluble fas ligand. 15905559 - Dendritic cell-intrinsic expression of nf-kappa b1 is required to promote optimal th2 c... 15347849 - Differences in airway remodeling between asthma and chronic obstructive pulmonary disease. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-03-15 |
Journal Detail:
|
Title: Journal of biomedicine & biotechnology Volume: 2010 ISSN: 1110-7251 ISO Abbreviation: J. Biomed. Biotechnol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-03-19 Completed Date: 2010-06-23 Revised Date: 2010-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 101135740 Medline TA: J Biomed Biotechnol Country: United States |
Other Details:
|
Languages: eng Pagination: 294389 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cytokines / immunology* Humans Immunity, Innate / immunology* Leishmaniasis, Cutaneous / immunology* Leishmaniasis, Visceral / immunology* Models, Immunological STAT Transcription Factors / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
AI068829/AI/NIAID NIH HHS; AI076309/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/STAT Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraosseous hemangioma of the inferior turbinate.
Next Document: The Effectiveness of an After-school Program Targeting Urban African American Youth.